So, comment away! Any prompts you like can go here; be as vague or as particular as you like. Make it general for any fandom (or no fandom), or make it specific to a character or two from one fandom. All I would say is that if you have more than one longish prompt, use a new comment.
And for anyone grabbing prompts to use in a story (or graphic or video or any other sort of creation! Remember we're an equal opportunity comm!), feel free to do so; you may want to let the prompter know you've filled it by replying to their comment here with a link, but it isn't compulsory. Have fun!